CD4 is an accessory molecule. This antigen binds to MHC class II molecules and is a co-receptor in MHC class II restricted antigen-induced activation. CD4 is expressed on T helper cells and at a lower level on thymocytes and monocytes. The CD4 molecule is a receptor for the HIV-1 envelope protein gp120 and plays an important role in the aggressive infection process.
Cell-Adembeads are superparamagnetic nanoparticles optimized for the positive selection and depletion of cells using commercially available separation columns.
Cell-Adembeads are designed for direct labeling of cells. We have developed a specific polymer on the surface of the beads and selected highly specific antibodies, thus reducing non specific capture and optimizing the separation.
The small size combined to the specific polymer allows the cells to be further evaluated in downstream application like flow cytometry or functional studies such as proliferation or cytotoxicity assay.